Negative cooperativity at the insulin receptor
نویسندگان
چکیده
منابع مشابه
Effect of monoclonal antibodies on human insulin receptor autophosphorylation, negative cooperativity, and down-regulation.
Three major functional characteristics of the insulin receptor are negative cooperativity, down-regulation, and beta-subunit tyrosine kinase activity. To investigate the inter-relationships among these functions we studied four antibodies to the insulin receptor alpha-subunit. These monoclonal antibodies competitively inhibited 125I-insulin binding to the insulin receptor of human IM-9 and HEP-...
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ژورنال
عنوان ژورنال: Nature
سال: 1981
ISSN: 0028-0836,1476-4687
DOI: 10.1038/289442a0